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Administration of an ER antagonist (ICI 182,780) to the hippocampus, but not the amygdala, increases anxiety and depression behavior. The antagonist applied to hippocampus decreased central open field entries (top panel) and time spent on the open arms of the plus maze (middle panel) but increased time spent immobile in the forced swim test (bottom panel). Error bars indicate one SEM. *p<0.05, antagonist vs vehicle.
