FIG. 1.

Interferon-stimulated genes (ISGs) involved in IFN-induced apoptosis and IFN resistance. Unphosphorylated (U)-STAT1, G1P3, and IFIT3 are the genes with antiapoptotic/survival function. G1P3 inhibits TRAIL-mediated cell death, and IFIT3 interacts with IFIT2 and disables its proapoptotic activity. AIM1, IP6K2, IFIT2, IFITM2, ISG12a, NUB1, NOXA, and TRAIL are the genes with apoptotic function. Note that some of these proteins are present in more than one cellular compartment. Please refer to Tables 1 and 2 for their correct subcellular localization. Many of these apoptotic gene products promote cell death via activation of the intrinsic mitochondrial-dependent death pathway.