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. 2012 Dec 2;136(1):43–64. doi: 10.1093/brain/aws307

Figure 6.

Figure 6

The phosphorylated TDP43 pathology of CTE and CTE-MND. (A) pTDP-43 immunostained neurites found in periventricular region of the third ventricle in CTE II. (B) CTE stage II demonstrating pTDP-43 immunostained neurites in a perivascular distribution. (C) pTDP-43 immunoreactive inclusion in locus coeruleus in CTE stage II. (D) Clusters of pTDP-43 immunoreactive neurites in the subpial region of the brainstem in stage III CTE. (E) Perivascular pTDP-43 neurites in stage III CTE. (F) Subpial pTDP-43 neurites in the corpus callosum of stage IV CTE. (G) Dense pTDP-43 abnormalities in the temporal cortex of stage IV CTE-MND. (H) Dense pTDP-43 pathology of CA1 hippocampus in stage IV CTE. (I–O) (I) perivascular focus at sulcal depth pTDP-43 abnormalities are widespread throughout the CNS in CTE associated with MND (CTE-MND) (J, corpus callosum; K, cerebral peduncle; L, fornix; M, subpial region of frontal cortex; N, perivascular region frontal cortex; O, Rolandic cortex). All images: 50-µm tissue sections, all scale bars = 100 µm.