Skip to main content
. Author manuscript; available in PMC: 2013 Apr 12.
Published in final edited form as: DNA Repair (Amst). 2012 Feb 15;11(4):381–390. doi: 10.1016/j.dnarep.2012.01.004

Table 3.

Distribution and frequency of errors produced by WT and D160N Pol β within the HSV-tk coding sequence.

Type of error Frequency × 10−4 (no. events)
Ratio D160N/β-WT
D160N β-WT
Pol EFest (HSV-tk coding region) 310 (90) 25 (68) 12
Base substitutions (independent) 55 (16) 2 (6) 28
Frameshifts (independent) 138 (40) 16 (43) 9
Tandem errors 117 (34) 7 (19) 17
 Simple 31 (9) 6 (17) 5
 Complex 86 (25) 0.7 (2) 123

The HSV-tk coding region Pol EF from Table 2 was averaged for both substrates, and the average used to calculate frequencies of specific error classes. Base substitutions and frameshifts are considered independent if they occur greater than 15 nucleotides apart. Tandem simple mutations refer to two single mutations that occur within 15 bases. Tandem complex mutations describe >2 mutations that occur within 15 bases.