Scheme 5. Synthetic Approach to Amide Derivatives.
(a) HCl (6 M), 3 h, reflux, 80–95% (ratio 10c/10d ∼ 90:10); (b) N,N-carbonyldiimidazole, THF, reflux, excess amine in MeOH, 0° C, 18-24 h; (c) TBTU, DIPEA, secondary amine, DMF, 0 °C; 18–24 h.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.