Table 1. LogD/LogP, Kinetic Solubility, in Vitro Intrinsic Clearance and Activity against P. falciparum for Ring A Variantsd.
Value measured using a chromatographic gLogD technique.
Estimated using nephelometry.
In vitro intrinsic clearance determined in mouse hepatic microsomes.
Chloroquine, EC50P. falciparum K1 0.095–0.172 μM; podophyllotoxin EC50 L6 cells 0.009–0.022 μM. The EC50 values are the means of two independent assays and varies less than ±50%. n.d = not determined.