Table 1.

Summary of the detected hotspots

Hotspot index	Sizea	Locib	GO categoryc	Hitsd	t-test (all)e	t-test (hits)f
NO. 1	32	Chr XII:1056103	Telomere maintenance via recombination	5	20	5
NO. 2	27	Chr IV:1525327	Telomere maintenance via recombination	4	5	3
NO. 3	26	Chr XII:662627	Sterol metabolic process	7	25	7
NO. 4	24	Chr I:52859	Fatty acid metabolic process	10	12	6
NO. 5	24	Chr XV:202370	Response to abiotic stimulus	10	11	6
NO. 6	23	Chr III:201166	Response to pheromone	7	16	6
NO. 7	21	Chr VII:402833	Protein folding	8	4	3
NO. 8	19	Chr I:7298	Fatty acid beta-oxidation	5	13	4
NO. 9	18	Chr IV:33214	Response to toxin	5	0	0
NO. 10	16	Chr II:562415	Cytokinesis	8	15	8
NO. 11	16	Chr X:698149	—	—	3	—
NO. 12	16	Chr XV:132423	—	—	13	—
NO. 13	15	Chr XIII:843356	Organic acid transport	5	0	0
NO. 14	15	Chr V:395442	—	—	3	—
NO. 15	15	Chr XVI:486637	Sexual reproduction	6	8	4

^aNumber of genes associated with the hotspot. ^bThe chromosome position of hotspot. ^cThe most significant GO category enriched in the associated gene set. The enrichment test was performed using DAVID (Huang da and Lempicki, 2008). The gene function is defined by GO Fat category. DAVID outputs the Benjamini–Hochberg adjusted P-value. Adjusted P-values are indicated by , where ^dNumber of associated genes that are functional in the enriched GO category. ^eNumber of associated genes that can also be identified using t-test. ^fNumber of associated genes that are functional in the enriched GO category and can also be identified using t-test. Two novel hotspots (NO. 9 and NO. 13) which cannot be detected by standard linear regression are in bold.