Figure 3.

Effect of nasal administration of AVE0118 given at time point 0 min on upper airway collapsibility at different levels of negative pressure and on the mechanoreceptor activation pressure threshold (right lower panel) in anesthetized pigs. Percentages of pigs (n = 6 per group) with collapse or mechanosensor activation thresholds (mbar) are given for vehicle (control), 1, 3, and 10 mg per nostril of AVE0118. Results for mechanoreceptor threshold after AVE0118 are significantly different versus vehicle for all doses and timepoints (P < 0.001). Results for collapsibility are significant versus vehicle group for time points > 30-60 min (P < 0.01) for all doses and pressures. At 1-mg duration of inhibition of collapsibility versus control group is 180, 120, and 75 min (medians; P < 0.01) at -50, -100, and -150 mbar, respectively.