Figure 3. A-type K⁺ channels regulated calcium release from ER stores during calcium waves in a three-cylinder neuronal model.

A, effect of the A-type conductance in the oblique dendrite on [Ca²⁺]_c during a Ca²⁺ wave. [Ca²⁺]_c traces were recorded at a distance of 8 μm from the branch point with different densities of the A conductance in the oblique dendrite. B–E, area under the curve (AUC) for the [Ca²⁺]_c transients depicted in A (B), full width at half maximum, FWHM (C) and latency-to-peak for these [Ca²⁺]_c transients (D) and AUC for the flux of Ca²⁺ through InsP₃ receptors, (E), in achieving these transients, plotted as functions of A-conductance density, . Plots are shown for different densities of the L-type Ca²⁺ channel, . F and G, time-dependent [Ca²⁺]_c changes (F) and the amplitude (G) of Ca²⁺ wave, computed in the presence of mobile buffers at different affinities (K_mob) to Ca²⁺ binding. Ca²⁺ wave was initiated with 100 μm mobile buffer with the same protocol as in A. H, AUC for plotted as functions of A-conductance density, , when the Ca²⁺ wave was initiated in the presence of 100 μm mobile buffer and with different values of K_mob.