Table 2.
Parameters used in calcium dynamics
| Parameter | Symbol | Value | Unit | Reference |
|---|---|---|---|---|
| Average amplitude of SERCA pump uptake | Vmax | 1 × 10−4 | mm ms−1 | |
| Leak constant | L | Determined by steady-state balance | mm ms−1 | (Fink et al. 2000) |
| Dissociation constant for Ca2+ binding to an activation site | Kact | 0.3 | μm | (Fink et al. 2000) |
| Dissociation constant for Ca2+ binding to an inhibition site | Kinh | 0.2 | μm | (Fink et al. 2000) |
| On-rate for Ca2+ binding to an inhibition site | kon | 2.7 | μm−1 s−1 | (Fink et al. 2000) |
| Dissociation constant for InsP3 binding to a channel | KInsP3 | 0.8 | μm | (Fink et al. 2000) |
| Dissociation constant for Ca2+ binding to a pump | Kp | 0.27 | μm | (Lytton et al. 1992) |
| Initial cytosolic Ca2+ concentration | [Ca2+]0 | 0.05 | μm | (Fink et al. 2000) |
| Ca2+ concentration in ER | [Ca2+]ER | 400 | μm | (Meldolesi & Pozzan, 1998) |
| Average rate of Ca2+ flux density at the plasma membrane | γ0 | 8.0 | μm s−1 | (Herrington et al. 1996) |
| Threshold condition for Ca2+ extrusion at plasma membrane | [Ca2+]crt | 0.2 | μm | (Herrington et al. 1996) |
| Ca2+ diffusion coefficient | DCa | 220 | μm2 s−1 | (Allbritton et al. 1992) |