Figure 2. LTD impairment by CaMKII inhibition was abolished by inhibition of PP-2A.

A and B, representative current traces (A) and time courses of amplitudes (B) of current response to glutamate before and after the coupled conditioning stimulation in the presence or absence of AIPII and nodularin. n = 5 for each. C and D, time courses of amplitudes of glutamate responses before and after the conditioning stimulation in the presence of KN62 and nodularin (C) or of AIPII and either fostriecin or Inhibitor-2 (D). n = 5 for each. E and F, representative images (E) and time course (F) of fluorescence ratio (F₃₄₀/F₃₈₀) of fura-4F before and after the conditioning depolarization. The conditioning depolarization consisted of 6 sets of depolarization pulses (0 mV for 1 s) applied every 20 s. n = 8 cells. G, peak fluorescence ratios of fura-4F in the secondary dendrite during each depolarization pulse in the absence or presence of an indicated pharmacological agent. n = 8 for each.