Figure 6. Short-term synaptic plasticity at both the parallel fibre–Purkinje cell synapse and at the climbing fibre–Purkinje cell synapse is impaired in 5-HT3A receptor knockout mice.
A–C, paired-pulse recordings from parallel fibre–Purkinje cell synapses at P8 in WT mice (Aa) and in 5-HT3A receptor knockout mice (Ab) and at P21 in WT mice (Ba) and in 5-HT3A receptor knockout mice (Bb). C, the paired-pulse ratio at the parallel fibre–Purkinje cell is reduced in 5-HT3A receptor knockout mice at P8, but not at P21. D–F, paired-pulse recordings from climbing fibre–Purkinje cell synapses at P8 in WT mice (Da) and in 5-HT3A receptor knockout mice (Db) and at P24 in WT mice (Ea) and in 5-HT3A receptor knockout mice (Eb). F, the paired-pulse ratio at the climbing fibre–Purkinje cell synapse is increased in 5-HT3A receptor knockout mice at P8–P9 and at P11–P12, but there is no difference at P24. The numbers in the bars of the graphs indicate the number of cells used for analysis.