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. 2012 Dec 24;591(Pt 7):1921–1934. doi: 10.1113/jphysiol.2012.247577

Figure 2. The effect of leptin on gastric vagal afferent mechanosensitivity is modified by high fat diet (HFD)-induced obesity.

Figure 2

Single fibre recording stimulus–response curves of mucosal (Aa, n= 5; Ab, n= 6) and tension (Ba, n= 5; Bb, n= 5) receptors to mucosal stroking and circular tension, respectively, in standard laboratory diet (SLD; Aa and Ba) and high-fat diet (HFD)-fed mice (Ab and Bb) before ○ and after exposure to leptin 0.1 nm□, 1 nM Δ and 10 nm◊. Ac and Bc, percentage change in response to 50 mg von Frey hair and 3 g tension, respectively, compared with control at varying concentrations of leptin in SLD (•) and HFD (▪) mice. *P < 0.05, **P < 0.01, ***P < 0.001 vs. control (two-way ANOVA). Data are expressed as mean ± SEM. C, original recording, from a SLD mouse, of a mucosal receptor response to mucosal stroking with a 50 mg von Frey hair (a) prior to leptin and (b) after addition of leptin (10 nm). D, original recording, from a HFD mouse, of a tension receptor response to 3 g circular tension (a) prior to leptin, (b) after addition of leptin (10 nm), and (c) the average spike shape of the tension receptor prior to leptin (continuous line) and after addition of leptin (dashed line), illustrating that both responses were obtained from the same unit.