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. 2012 Dec 24;591(Pt 7):1921–1934. doi: 10.1113/jphysiol.2012.247577

Figure 6. Leptin inhibits gastric tension receptors through phosphatidylinositol 3-kinase (PI3K) activation of large-conductance calcium-activated potassium channel (BKCa) in fasted mice.

Figure 6

Single fibre recording stimulus–response curves of tension receptors to circular tension in fasted mice (Aa–f, n= 5) before ○ and after exposure to the second messenger inhibitors (a: AG490 – 5 μm; b: wortmannin – 5 nm; c: iberiotoxin – 100 nm; d: cilostamide – 5 μm; e: U73122 – 10 μm; f: 2-APB – 30 μm) □, and in the presence of the respective second messenger inhibitor and leptin 10 nmΔ. **P < 0.01, ***P < 0.001 vs. control (leptin effect: two-way ANOVA). B, expression of KCa1.1 mRNA in whole nodose ganglia (NDG) of fed and fasted mice (*P < 0.05; unpaired t test). Data are expressed as mean ± SEM.