Figure 6. NR2B subunit was a dominant NMDAR at the presynaptic terminals in neuropathic rats.

Original recordings show samples of EPSCs evoked by a pair of electrical pulses recorded from a neuron of neuropathic rats before (baseline), during and after washout of Ro 25-6981 (1 μm). Bar graphs (right) show the mean (+SEM) amplitudes and P2/P1 ratios before, during and after washout of Ro 25-6981. Bath application of Ro 25-6981 significantly and reversibly reduced the first peak amplitudes but increased the P2/P1 ratio. **P < 0.01; ***P < 0.001.