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Clots treated with fibrin-targeted PARACEST nanoparticles showed higher PARACEST CNR (Left) and higher concentration of bound nanoparticles (Right) compared to control clots (* p < 0.05). When bound to the clot, the PARACEST minimum detection limit (CNR = 5) is reduced to 2.30 nM, presumably due to alteration of the bound water lifetime. The error bars represent the standard error of the mean for each group of clots.
