Table 1.

PI3K-related kinase isoform selectivity of compounds used in in vitro studies

Drug	Specified targets	IC50				References
		PI3K	mTOR	DNA-PK	ATM
BEZ235	PI3K/mTOR	4-75 nM	8 nM	1.7 nM	<100 nM	23, 38, 39, 40
BKM120	PI3K	2-262 nM	2.9 μM	>10 μM	N/R	46
Everolimus	mTORC1	N/A	<10 nM	N/A	N/A	23
KU63794	mTORC1/2	>10 μM	10 nM	N/R	N/R	47
KU57788	DNA-PK	5 μM	1.7 μM	14 nM	>100 nM	48
KU55933	ATM	17 μM	9 μM	2.5 μM	13 nM	45

Kinase inhibition 50% inhibitory concentration (IC₅₀) for each compound as reported in selected references. Targets inhibited in the nanomolar concentration range are in italics.

N/A, not applicable, N/R, not reported.