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. 2013 Mar 25;48(1):10–15. doi: 10.5045/br.2013.48.1.10

Fig. 1.

Fig. 1

Inflammation increases interleukin-6 production. The consequent increase in hepcidin blocks macrophage iron release as well as the intestinal absorption of iron, resulting in hypoferremia. Abbreviations: TF, transferrin; Fe, iron; DMT1, divalent metal transporter 1.