Skip to main content
. 2013 Feb 13;33(7):3178–3189. doi: 10.1523/JNEUROSCI.2428-12.2013

Figure 7.

Figure 7.

FATP4 prevents degeneration of rod photoreceptors induced by intense light. A, SD-OCT shows similar structures of superior retinas in 129S2/Sv (WT) and Fatp4−/− mice before intense light exposure (ILE). RPE, outer nuclear layer (ONL), and inner nuclear layer (INL) are indicated. B, C, OCT and light microscopy show retinal (mainly rods) degeneration in the superior retina of Fatp4−/− mice exposed to 15,000 lux for 1.5 h. D, Retinal outer nuclear layer thickness in WT and Fatp4−/− mice exposed to intense light. Numbers on the x-axis indicate distance from optic nerve head. Error bars indicate SD (n = 3). E, Immunoblots for rhodopsin (Rho) in WT and Fatp4−/− retinas exposed to intense light. Bands corresponding to Rho dimers and monomers are indicated. F, Contents of atRAL in the retinas of WT and Fatp4−/− mice exposed to 2000 lux light for 1 h. *Statistically significant difference (p < 0.05). Error bars indicate SD (n = 3).