Table 1.

Risk of colorectal cancer in gene mutation carriers.

Syndrome	Risk in mutation carriers
FAP	90% by age 45 years
Attenuated FAP	69% by age 80 years
Lynch syndrome	40–80% by age 75 years
MYH*-associated polyposis	35–53%
Peutz-Jeghers syndrome	39% by age 70 years
Juvenile polyposis syndrome	17–68% by age 60 years

Although absolute risk is clearly higher than average risk in the general population, note the impact of age and range of risk depending on time to expose to the environment factors.

Guidelines of National Cancer Institute at the National Institutes of Health (http://www.cancer.gov/cancertopics/pdq/genetics/colorectal/HealthProfessional).

FAP, familial adenomatous polyposis. *MYH: MUTYH (mutY Homolog (E. coli) gene) is a human gene located on the short arm (p) of chromosome 1.