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. Author manuscript; available in PMC: 2013 Apr 12.
Published in final edited form as: Physiology (Bethesda). 2010 Oct;25(5):280–292. doi: 10.1152/physiol.00022.2010

FIGURE 3. Mechanisms of adaptor protein interaction with cargo and clathrin.

FIGURE 3

AP-2 and clathrin- and lipid-associated sorting proteins (CLASPs) have the capacity to simultaneously interact with clathrin (clathrin box) and internalization signals on cargo proteins. Shown are schematic views of the tetrameric AP-2 adaptor protein complex UIM (ubiquitin-interacting motifs)-CLASPS and PTB (phosphotyrosine-binding domain)-containing-CLASPs and their cognate internalization signals. In addition to interacting with clathrin and cargo, the CLASPs also are capable of interacting with AP-2.