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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Feb 13;23(7):2035–2043. doi: 10.1016/j.bmcl.2013.02.019

Figure 1.

Figure 1

(A) The TgENR/NAD+/triclosan crystal structure shown in a cartoon representation covered by a transparent surface showing the channel which leads from the triclosan inhibitor to the outside solvent. TgENR Asn130 which has been targeted for the design of new inhibitors is shown in stick format close to the B-ring of triclosan. (B) A multiple sequence alignment in the vicinity of TgENR Asn130 (shown by an asterisk) of a number of parasitic and plant ENR enzymes showing full sequence conservation across parasite and plant families.