Table 1. Examples of model system nomenclature.
Gene | Protein | ||
---|---|---|---|
|
WT |
Mutant |
|
Human |
ULK1 |
ULK1−/− |
ULK1 |
Mouse |
Ulk1 |
ulk1 |
ULK1 |
Rat |
Ulk1 |
ulk1 |
ULK1 |
Chicken |
ULK1 |
ULK1−/− |
ULK1 |
Xenopus |
ulk1 |
ulk1 |
ulk1 |
Zebrafish |
ulk1a |
ulk1a |
Ulk1a |
Caenorhabditis |
unc-51/atg-1a |
unc-51(-)b |
UNC-51/ATG-1 |
Arabidopsis |
ATG1a |
atg1a |
ATG1a |
Yeast | ATG1 | atg1c | Atg1 |
aatg-1 is an alias; however, in this case the “other name” may actually help avoid confusion by clearly identifying the gene as a homolog of ATG1. Most of the C. elegans atg genes that have non-atg designations have “other names” that incorporate the yeast ATG nomenclature. For example, lgg-1/atg-8.1 and bec-1/atg-6. We recommend that authors use both names at least for the initial time the gene is mentioned in a paper. bMutants can also be expressed by specific allele designations, as in unc-51(e369) or more generally as unc-51(lof) to indicate loss of function. cAllele designations typically take the form of the gene name followed by a dash and an allele number, as in atg1-17. This is one reason that a protein-protein interaction such as Atg12–Atg5 should not be abbreviated as "Atg12-5."