Table 1. Steady-State Kinetic Constants for NDM-1 and Various Substrates.

substrate class	substrate	nm	Km( µM)	kcat(s−1)	kcat/Km( µM−1s−1)
penem	penicillin G	235	103	27.5	0.27
	piperacillin	230	69	8.3	0.12
cephem	cefoxitin	230	63	38.3	0.61
	ceftazidime	260	74	60.9	0.83
carbapenem	cefotaxime	260	43	31.5	0.74
	biapenem	294	155	105.6	0.68
	meropenem	297	42	30.75	0.73