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. 2013 Apr 12;8(4):e60718. doi: 10.1371/journal.pone.0060718

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© 2013 Granic, Potter

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(A–C) Quantitative FISH analysis with a dually labeled DNA probe for chromosomes 21 and 12 showed a significant reduction in trisomy 21 (A), tetrasomy 21 and tetrasomy 12 (B) in hTERT cells pre-treated with 1.5 mM of Ca++ chelator EGTA followed by OX-LDL compared to cells treated only with OX-LDL. Cells pre-treated with 1 mM BAPTA had significantly lower levels of OX-LDL-induced trisomy 21 and trisomy 12 (C) compared to the cells grown without chelator.