Table 1. Ratio of amino acid replacing (Ka) and silent (Ks) mutation rates for all pairwise comparisons of five tetrapod PKA Cα homologs and five primate PKA Cγ homologs.
| Ka/Ksa | ||||
| H. sapiens Cα | O. garnettii Cα | M. musculus Cα | B. taurus Cα | |
| O. garnettii Cα | 0.0159 (0.0158) | |||
| M. musculus Cα | 0.0141 (0.0141) | 0.0230 (0.0226) | ||
| B. taurus Cα | 0.0064 (0.0063) | 0.0116 (0.0111) | 0.0156 (0.0158) | |
| X. tropicalis Cα | 0.0065 (0.0060) | 0.0055 (0.0056) | 0.0065 (0.0064) | 0.0059 (0.0060) |
| K a/ K s b | ||||
| H. sapiens Cγ | P. troglodytes Cγ | P. pygmaeus Cγ | G. gorilla Cγ | |
| P. troglodytes Cγ | 0.135 (0.127) | |||
| P. pygmaeus Cγ | 0.290 (0.324) | 0.175 (0.194) | ||
| G. gorilla Cγ | 1.360 (1.207) | 0.162 (0.148) | 0.295 (0.319) | |
| M. mulatta Cγ | 0.697 (0.678) | 0.419 (0.406) | 0.393 (0.393) | 0.621 (0.603) |
a
Ka/Ks ratios for pairwise comparisons of PKA Cα from human, a prosimian primate (O. garnettii), mouse (M. musculus), cattle (B. taurus) and a frog (X. tropicalis) calculated according to the model of Goldman and Yang [89] and the model averaging method of Zhang et al. (in parenthesis) [90] for the Core16–350 sequence segment.
b
Ka/Ks ratios for pairwise comparisons of PKA Cγ from human, chimpanzee (P. troglodytes), orangutan (P. pygmaeus), gorilla (G. gorilla) and rhesus macaque (M. mulatta) calculated as described above.