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. 2013 Mar 25;110(15):5797–5801. doi: 10.1073/pnas.1219686110

Table 1.

Social isolation, loneliness, and risk factors

Patient characteristics Social isolation P value Loneliness P value
Low/average (n = 5,269) (%) High (n = 1,231) (%) Low/average (n = 5,325) (%) High (n =1,175) (%)
Sex
 Male 2,378 (45.1) 575 (46.7) 0.32 2,522 (47.4) 431 (36.7) <0.001
 Female 2,891 (54.9) 656 (53.3) 2,803 (52.6) 744 (63.3)
Age (y)
 <60 1,709 (32.4) 353 (28.7) <0.001 1,719 (32.3) 343 (29.2) <0.001
 60–69 1,888 (35.8) 359 (29.2) 1,904 (35.8) 343 (29.2)
 70–79 1,219 (23.1) 325 (26.4) 1,248 (23.4) 296 (25.2)
 80+ 453 (8.6) 194 (15.8) 454 (8.5) 193 (16.4)
Education
 No qualifications 1,675 (31.8) 572 (46.5) <0.001 1,733 (32.5) 514 (43.7) <0.001
 Intermediate 2,099 (39.8) 435 (35.3) 2,101 (39.5) 433 (36.9)
 Higher education 1,495 (28.4) 224 (18.2) 1,491 (28.0) 228 (19.4)
Ethnicity (White) 5,202 (98.7) 1,217 (98.9) 0.78 5,266 (98.9) 1,153 (98.1) 0.041
Wealth quintile
 1 (lowest) 720 (13.7) 382 (31.0) <0.001 793 (14.9) 309 (26.3) <0.001
 2 990 (18.8) 270 (21.9) 984 (18.5) 276 (23.5)
 3 1,101 (20.9) 223 (18.1) 1,095 (20.6) 229 (19.5)
 4 1,208 (22.9) 183 (14.9) 1,191 (22.4) 200 (17.0)
 5 (highest) 1,250 (23.7) 173 (14.1) 1,262 (23.7) 161 (13.7)
Married 4,089 (77.6) 388 (31.5) <0.001 3,971 (74.6) 506 (43.1) <0.001
Limiting long-standing illness 1,629 (30.9) 485 (39.4) <0.001 1,540 (28.9) 574 (48.9) <0.001
 Cancer 168 (3.2) 36 (2.9) 0.72 171 (3.2) 33 (2.8) 0.52
 Diabetes 332 (6.3) 89 (7.2) 0.25 332 (6.2) 89 (7.6) 0.10
 CHD 193 (3.7) 43 (3.5) 0.87 176 (3.3) 60 (5.1) 0.004
 Chronic lung disease 65 (1.2) 34 (2.8) <0.001 71 (1.3) 28 (2.4) 0.012
 Stroke 134 (2.5) 43 (3.5) 0.079 117 (2.2) 60 (5.1) <0.001
 Arthritis 1,778 (33.7) 477 (38.7) 0.001 1,714 (32.3) 541 (46.0) <0.001
 Mobility impairment 2,940 (55.8) 769 (62.5) <0.001 2871(53.9) 838 (71.3) <0.001
 Clinical depression 77 (1.5) 21(1.7) 0.52 59 (1.1) 39 (3.3) <0.001
 Depression symptoms above threshold 883 (16.8) 338 (27.5) <0.001 690 (13.0) 531 (45.2) <0.001