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. 2013 Mar 25;110(15):5797–5801. doi: 10.1073/pnas.1219686110

Table 2.

Association between social isolation and mortality

Model Covariates Social isolation
HR (95% C.I.) P value
1 Isolation + age + sex 1.50 (1.30–1.73) <0.001
2 Isolation + age + sex + demographic factors* 1.32 (1.12–1.54) <0.001
3 Isolation + age + sex + demographic factors* + health indicators 1.26 (1.07–1.48) 0.005
4 Model 3 + loneliness 1.26 (1.08–1.48) 0.004

*Demographic factors are wealth, education, marital status, and ethnicity.

Health indicator are limiting long-standing illness, mobility impairment, cancer, diabetes, CHD, chronic lung disease, arthritis, stroke, diagnosed depression, and CES-D rating.