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NOX-D19–treated C3−/− recipients exhibit reduced collagen deposition and fibrotic remodeling. (A) Representative H&E images of orthotopic tracheal transplants 28 d posttransplantation. (B) Picrosirius red staining for collagen deposition on day 28. E and SE, graft epithelial and subepithelial areas, respectively. Original magnification, 40×. (C) Total collagen quantification for WT Syn, WT Allo vs. C3−/− Allo groups (n = 4–6 per group). Data are shown as means with SEM. *P < 0.05.
