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HTS identifies the P. yoelii ribosomal protein L3 as a T-cell antigen. (A) Subset of wells from primary HTS showing positive result in pool 171. (B) Pool 171-specific responses in naïve vs. sporozoite-immunized mice. (C) Deconvolution of pool 171 using individual minigenes shows that minigene 171.3 (from L3 ribosomal protein, PY05881) was the antigenic component of the pool.
