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. Author manuscript; available in PMC: 2014 Feb 27.
Published in final edited form as: J Am Chem Soc. 2013 Feb 8;135(8):3173–3185. doi: 10.1021/ja311408y

Figure 6. Conformation affects insulin binding to its receptor.

Figure 6

(a) Schematic illustration of conformational change of insulin upon its binding to the receptor, after Weiss et al.49 Chains A and B are schematically shown as brown and green regions, respectively. Residues IleA2, ValA3, ValB12, PheB24, and PheB25 implicated in binding to the insulin receptor are schematically shown. (b) Schematic model of ester insulin ‘locked’ in an unproductive conformation by the ester tether.