TABLE 2.

Fracture rate stratified by dose of androgen-deprivation therapy (ADT), attempted curative treatment and the baseline risk of skeletal complications

Baseline risk ADT dose	Low risk		High risk
	Person years	Event rate per 1000	Person years	Event rate per 1000
ADT only
No ADT	61 820	28.9	35 150	52.9
1–5	3274	35.4	2377	48.4
6–17	5544	30.3	5565	67.9
≥18*	20 418	50.1	28 182	73.0
Orchidectomy	3870	57.4	4664	85.8
ADT + attempted curative treatment†
No ADT	234 983	25.9	51 599	45.2
1–5	50 329	27.4	15 899	48.7
6–17	43 506	30.5	16 787	54.4
≥18*	23 746	38.7	10 768	59.4
Orchidectomy	1630	41.7	550	60.0

The incidence rate of fracture was significantly associated with the risk of skeletal complications and the dose of ADT. Tests were examined by Poisson regression.

^*≥18 years: no more than 48 doses

^†Attempted curative treatments: men received radiation therapy or radical prostatectomy within 1 year of cancer diagnosis.