Table 4.
Up-regulated genes in rat zG in the aldosterone synthetic pathways
| gene | gene # | p-value | fold change |
gene definition |
|---|---|---|---|---|
|
renin angiotensin system related genes |
||||
| Agtr1a | #37 | <0.05 | 11.1 | angiotensin II receptor, type 1a |
| Agtr1b | #34 | <0.05 | 11.7 | angiotensin II receptor, type 1b |
| Agtr2 | n.a. | 0.094 | 2.1 | angiotensin II receptor, type 2 |
| Cyp11b2 | #1 | <0.05 | 214.2 | cytochrome P450, family 11, subfamily B, polypeptide 2 (aldosterone synthase) |
| potassium-related genes | ||||
| potassium channels | ||||
| Kcnn2 | #19 | <0.05 | 17.5 | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 |
| potassium transporting ATPase | ||||
| Atp1b1 | n.a. | 0.052 | 3.5 | ATPase, Na+/K+ transporting, beta 1 polypeptide |
| Atp1b2 | #118 | <0.05 | 4.5 | ATPase, Na+/K+ transporting, beta 2 polypeptide |
| calcium-related genes | ||||
| calcium channels | ||||
| Cacna1c | #176 | <0.05 | 3.0 | calcium channel, voltage-dependent, L type, alpha 1C subunit |
| Cacna1d | #218 | <0.05 | 2.3 | calcium channel, voltage-dependent, L type, alpha 1D subunit |
| Cacna1h | n.a. | 0.082 | 2.6 | calcium channel, voltage-dependent, T type, alpha 1H subunit |
| Cacnb3 | #119 | <0.05 | 4.5 | calcium channel, voltage-dependent, beta 3 subunit |
| calmodulins | ||||
| Calm1 | n.a. | 0.069 | 2.7 | calmodulin 1 |
| Calm4 | n.a. | 0.100 | 2.2 | calmodulin 4 |
| calcium transporting ATPase | ||||
| Atp2a2 | #175 | <0.05 | 3.0 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 |
| Atp2a3 | n.a. | 0.063 | 4.1 | ATPase, Ca++ transporting, ubiquitous |
| Atp2c1 | #81 | <0.05 | 5.9 | ATPase, Ca++ sequestering |
|
inositol 1,4,5-triphosphate receptors |
||||
| Itpr1 | n.a. | 0.095 | 2.8 | inositol 1,4,5-triphosphate receptor 1 |
| others | ||||
| adenylate cyclases | ||||
| Adcy2 | n.a. | 0.056 | 3.8 | adenylate cyclase 2 |
| Adcy3 | #159 | 0.021 | 3.4 | adenylate cyclase 3 |
| Adcy4 | #53 | 0.022 | 7.8 | adenylate cyclase 4 |
| protein kinases | ||||
| Prkcz | n.a. | 0.090 | 2.6 | protein kinase C, zeta |
The gene # is assigned in order of fold changes. See Supplemental Table 1. n.a.: not available in Supplemental Table 1 due to p>0.05. P-values were calculated using a modified t test along with multiple testing corrections with the Benjamini and Hochberg false discovery rate.