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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Autoimmun Rev. 2012 Dec 29;12(7):741–751. doi: 10.1016/j.autrev.2012.12.007

TABLE 2.

List of important reactive nitrogen intermediates and their sources and modes of action

Source Modes of action/effects
Nitric oxide (NO) Nitric oxide synthase Nitrosylation of metal centers
Redox signaling
Peroxynitrite (ONOO−) Reaction between NO and SO Nitration
Oxidation
Oxidative stress
Nitrogen dioxide radical (NO) Reaction between NO and O2 Nitration
Oxidation
Oxidative stress
Dinitrogen trioxide (N2O3) Reaction between NO and NO2 Nitrosation
Nitrosative stress