Figure 1.
Serum transgene-encoded Ig in BWF1, BXSB, and NZB lupus mice. A) Laminin binding: OD405 on antigen coated wells minus the OD405 on diluent-only coated wells, based on duplicate serum samples. The positive control is anti-laminin supernatant A10C. Only Tg+ mice are shown. B) IgMa (transgenic Ig) concentration for Tg+ relative to non-transgenic subjects for each strain. Results are expressed as the mean ± SD; all Tg+ to non-Tg comparisons within the same strain are p<0.05. Number of subjects, from 5-12 independent experiments per strain, is shown in parenthesis.