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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Autoimmunity. 2013 Jan 9;46(3):188–204. doi: 10.3109/08916934.2012.746671

Figure 7.

Figure 7

Splenic B cell expression of CD23 and CD21/35 and marginal zone markers. A) Representative fluorescence intensity histograms of CD23-PE or CD21/35-FITC on B220+ gated B cells from LamH Ig transgenic lupus mice (bold line) relative to B cells from non-Tg controls of the same strain (light grey line). B) Scatterplot of normalized mean fluorescence intensity of CD21/35 on BXSB, NZB, and BWF1 Tg+ B cells. Fluorescence was normalized in each experiment to the mean fluorescence of non-Tg subjects for each strain, shown for BXSB. C) Scatterplot of the percentage of B220+ cells identified as marginal zone cells by the CD21+ CD1d+ marker combination in LamH Ig Tg mice and non-Tg controls. BXSB mice used for marginal zone analysis were 14-15.5 months of age, excepting two non-Tg BXSB males who were 4.5 and 5.5 months of age. *p<0.05 vs non-Tg.