Table 1.
B cell profiles of LamH Tg+ and Non-Tg spleen (A) and Bone marrow (B) by lupus strain a
| BWF1 | BXSB | NZB | MRL/lpr | |||||
|---|---|---|---|---|---|---|---|---|
| Non-Tg | Tg+ | Non-Tg | Tg+ | Non-Tg | Tg+ | Non-Tg | Tg+ | |
| A. Spleen | ||||||||
|
B cells (millions) |
23.2 ± 6.1 (13) |
5.4 ± 2.9* (15) |
60.6 ± 26.7 (31) |
10.6 ± 5.3* (41) |
18.2 ± 4.0 (18) |
3.6 ± 1.6* (24) |
31.2± 18.9 (11) |
6.4 ± 4.7* (15) |
|
% B cell decrease (vs Non-Tg) |
- | 76.7 | - | 82.5 | - | 80.2 | - | 75.6 |
| %IgMa+ | 3.3 ± 3.1 (13) |
82.6 ± 8.9* (15) |
1.7 ± 1.8 (30) |
86.7 ± 6.5* (41) |
1.9 ± 1.3 (18) |
61.1 ± 11.5* (24) |
||
| %IgMb+ | 84.3 ± 7.9 (13) |
15.8 ± 6.9* (15) |
82.6 ± 8.3 (30) |
12.9 ± 4.9* (41) |
80.9 ± 7.2 (18) |
24.4 ± 12.7* (24) |
||
| %Lambda+ | 3.2 ± 1.1 (13) |
2.0 ± 1.0* (15) |
3.7 ± 1.5 (19) |
7.1 ± 2.5* (26) |
5.5 ± 1.8 (11) |
8.9 ± 4.3* (14) |
11.6± 9.1 (7) |
6.9 ± 3.8 (7) |
|
Surface Ig MFI |
1.0 ± 0.2 (13) |
0.6 ± 0.3* (15) |
1.0 ± 0.1 (19) |
1.0 ± 0.1 (21) |
1.0 ± 0.1 (13) |
0.6 ± 0.1* (16) |
1.0 ± 0.1 (7) |
0.4 ± 0.2* (7) |
| B. Bone Marrow | ||||||||
|
% B cells Of lymph |
42.9 ± 11.7 (13) |
35.1 ± 15.4 (15) |
45.6 ± 13.1 (23) |
27.5 ± 10.7* (27) |
32.8 ± 13.3 (18) |
23.4 ± 10.3* (24) |
10.8 ± 5.4 (5) |
3.7 ± 1.9 (5) |
|
%IgM+ of B cells |
44.0 ± 7.5 (13) |
30.3 ± 6.1* (15) |
51.5 ± 16.9 (26) |
34.6 ± 7.5* (34) |
47.6 ± 16.1 (17) |
33.3 ± 20.2* (20) |
37.8 ± 14.7 (5) |
27.8 ± 7.2 (5) |
a
Data expressed as mean ± SD; number of subjects is shown in parenthesis. Average age of subjects included in this table, in months: BWF1 non-Tg: 3.4 ± 1.5, Tg+: 3.7 ± 1.3; BXSB non-Tg: 4.6 ± 2.3, Tg+: 5.1 ± 2.2; NZB non-Tg: 3.9 ± 2.0, Tg+ 4.5 ± 2.3; MRL/lpr non-Tg: 4.6 ± 1.8, Tg+ 4.4 ± 1.5.
*
p<0.05 versus non-Tg of the same strain.