Table 2.
Statistically significant associations in group with early knee OA (grade = 1) with ADAM12 gene SNPs (were observed only for rs1044122).
| Grade 0 | Grade 1 | OR (95% CI) | P value | Corrected P value** | |
|---|---|---|---|---|---|
| Rs1044122, whole group | OA in TFJ |
||||
|
| |||||
| A allele | 61% | 68% | 1.37 (1.01–1.87) | 0.042 | 0.087 |
| AA | 82 (39%) | 79 (43%) | 2.43 (1.17–5.05) | 0.017 | 0.036 |
| AG | 93 (45%) | 92 (50%) | 3.26 (1.10–4.62) | 0.026 | 0.054 |
| GG | 34 (16%) | 14 (7%) | 1* | 1* | |
|
| |||||
| Rs1044122, females | OA in TFJ | ||||
|
| |||||
| A allele | 60% | 70% | 1.63 (1.12–2.37) | 0.018 | 0.038 |
| AA | 53 (37%) | 58 (44%) | 3.78 (1.5–9.54) | 0.005 | 0.010 |
| AG | 66 (46%) | 65 (50%) | 2.92 (1.18–7.23) | 0.021 | 0.043 |
| GG | 24 (17%) | 8 (6%) | 1* | 1* | |
|
| |||||
| Rs1044122, females | OPH in TFJ | ||||
|
| |||||
| A allele | 60% | 70% | 1.57 (1.08–2.29) | 0.018 | 0.038 |
| AA | 61 (37%) | 50 (45%) | 3.81 (1.42–10.23) | 0.008 | 0.017 |
| AG | 76 (47%) | 56 (50%) | 3.09 (1.17–8.16) | 0.023 | 0.048 |
| GG | 26 (16%) | 6 (5%) | 1* | 1* | |
OA in TFJ: radiographic osteoarthritis in tibiofemoral joint; OPH in TFJ: osteophytes in tibiofemoral joint; *GG genotypes were analysed as base; **for multiple comparison correction Benjamini and Yekutieli method was used; in bold are shown statistically significant P values.