Table 2.
Clinical and echocardiographic findings of patients with health care-associated native valve endocarditis and comparison with those with community-acquired endocarditis
| All NVE
|
p value | Health care-associated NVE
|
p value | |||
|---|---|---|---|---|---|---|
| Community-acquired (n=1065) | Health care-associated (n=557) | Nosocomial (n=303) | Non-nosocomial (n=254) | |||
| Clinical findings at presentation: | ||||||
| - Fever | 913/945 (96%) | 461/489 (94%) | 0.23 | 257/273 (94%) | 204/216 (94%) | 0.89 |
| - New murmur or worsening of old murmur | 609/881 (69%) | 272/456 (60%) | 0.001 | 137/250 (55%) | 135/206 (66%) | 0.020 |
| - Vascular/immunologic evidence of endocarditis* | 275/1028 (27%) | 117/538 (22%) | 0.030 | 62/289 (21%) | 55/249 (22%) | 0.86 |
| - Splenomegaly | 131/1027 (13%) | 44/537 (8%) | 0.007 | 27/288 (9%) | 17/249 (7%) | 0.28 |
| Echocardiographic findings: | ||||||
| Vegetations: | 952/1058 (90%) | 510/554 (92%) | 0.173 | 276/301 (92%) | 324/253 (92%) | 0.73 |
| - Mitral valve | 503/1049 (48%) | 277/547 (51%) | 0.31 | 149/297 (50%) | 128/250 (51%) | 0.81 |
| - Aortic valve | 474/1049 (45%) | 193/547 (35%) | <0.001 | 102/297 (34%) | 91/250 (36%) | 0.62 |
| - Tricuspid valve | 76/1048 (7%) | 85/547 (16%) | <0.001 | 53/297 (18%) | 32/250 (13%) | 0.105 |
| - Pulmonary valve | 15/1048 (1%) | 4/547 (1%) | 0.22 | 3/297 (1%) | 1/250 (0.4%) | 0.40 |
| Paravalvular complications† | 245/1044 (23%) | 107/545(20%) | 0.081 | 63/293 (22%) | 44/252 (17%) | 0.23 |
NVE=native valve endocarditis
*
Includes Osler nodes, Janeway lesions, Roth spots, conjunctival hemorrhage, or vascular embolic events.
†
Paravalvular complications include abscess, valvular perforation, or cardiac fistula.