. Author manuscript; available in PMC: 2013 Apr 14.

Published in final edited form as: Psychosom Med. 2010 May 13;72(5):427–433. doi: 10.1097/PSY.0b013e3181de30ad

TABLE 3.

Overall MANOVA Tests for Gene (rs439401) × Group (Caregiver/Control) Effects on Metabolic Variables, With Univariate Tests of the Gene × Group Interaction for Each Variable

Metabolic Variable	Gene × Group^a (Additive Model) F (df)	p	Gene × Group^a (Dominant Model) F (df)	p
MANOVA (Wilk's Lambda)	1.83 (12 of 450)	.041	2.93 (6/227)	.009
Waist circumference	3.10 (2 of 230)	.047	5.00 (1 of 232)	.026
Fasting glucose	0.67 (2 of 230)	.515	0.03 (1 of 232)	.86
Fasting insulin (log)	1.67 (2 of 230)	.19	1.18 (1 of 232)	.28
HOMA-IR (log)	1.90 (2 of 230)	.15	1.08 (1 of 232)	.30
Fasting HDL cholesterol	5.68 (2 of 230)	.001	11.14 (1 of 232)	.001
Fasting triglycerides (log)	5.35 (2 of 230)	.005	10.84 (1 of 232)	.001

Covariates: age, gender, diabetes medications, hypertension medications, lipid-lowering medications.

MANOVA = multivariate analysis of variance; HOMA-IR = homeostatic model of insulin resistance; HDL = high-density lipoprotein.