Table IV.
Multivariate Logistic Regression of Factors Associated with Current Hydroxyurea (HU) Use
| Characteristic | Odds Ratio | 95% Confidence Interval | P value |
|---|---|---|---|
|
| |||
| Child’s Age | 0.99 | 0.9, 1.1 | 0.9 |
|
| |||
| Parental Knowledge of HU1 | |||
|
| |||
| No Knowledge | 1.0 | Ref | Ref |
|
|
|||
| Some knowledge | 13.9 | 4.7, 40.8 | <0.001 |
|
|
|||
| Significant knowledge | 21.3 | 6.6, 68.5 | <0.001 |
|
| |||
| Child’s Sickle Cell Genotype | |||
|
| |||
| Hemoglobin SS disease | 1.0 | Ref | Ref |
|
|
|||
| Hemoglobin SC disease | 0.14 | 0.04, 0.6 | 0.005 |
|
|
|||
| Hemoglobin S-Beta0 thalassemia disease | 0.18 | 0.02, 1.7 | 0.13 |
|
| |||
| Care at Institution | |||
|
| |||
| Institution A | 1.0 | Ref | Ref |
|
|
|||
| Institution B | 3.3 | 0.96, 11.1 | 0.06 |
|
|
|||
| Institution C | 0.4 | 0.06, 3.2 | 0.4 |
|
|
|||
| Institution D | 0.7 | 0.09, 5.7 | 0.8 |
|
|
|||
| Institution E | 0.2 | 0.06, 0.9 | 0.04 |
Regression model includes child’s age, parental knowledge, child’s sickle cell genotype, institution; Reference groups shown above with odds ratio of 1.0; Bold font indicates statistical significance;
1
Knowledge of HU: Some knowledge defined as: answered 1–2 knowledge questions correctly about HU, significant knowledge defined as: answered 3–4 knowledge questions correctly about HU.