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. Author manuscript; available in PMC: 2014 Jun 20.
Published in final edited form as: Neuroscience. 2012 Dec 20;0:83–89. doi: 10.1016/j.neuroscience.2012.12.020

Figure 4. Effect of sumatriptan (5-HT1B/D agonist) on endothelin-1 (A), epinephrine (B) induced mechanical hyperalgesia and stimulus-induced hyperalgesia and on PGE2 (C) induced mechanical hyperalgesia.

Figure 4

Intradermal administration of sumatriptan (5 µg/paw) 15 min prior to endothelin, attenuated endothelin hyperalgesia and stimulus-induced enhancement of endothelin hyperalgesia (A, for both P < 0.001, two way repeated measures ANOVA followed by Bonferroni post test, n = 8/group), whereas sumatriptan treatment 15 min prior to epinephrine, only attenuated stimulus-induced enhancement of epinephrine hyperalgesia (B, P < 0.001, two way repeated measures ANOVA followed by Bonferroni post test, comparing results within and between groups at different time points, n = 8/group). Intradermal administration sumatriptan 15 min prior to PGE2 (100 ng) had no effect on PGE2 hyperalgesia (C, n = 6).