Table 1.
Characteristics of the MDCS cohort according to the FTO rs9939609 genotype
| rs9939609 | |||||
|---|---|---|---|---|---|
|
|
|||||
| Variables | TT n=7898 | AT n=10982 | AA n=3919 | P for trenda | P for trendb |
| BMI kg/m2 | 25.4 (25.3–25.5) | 25.7 (25.6–25.8) | 26.0 (25.9–26.1) | <0.001 | |
| Total energy (MJ) | 9.9 (9.9–10.0) | 9.8 (9.8–9.9) | 9.8 (9.7–9.9) | 0.001 | 0.046 |
| Carbohydrates E% | 45.0 (45.0–44.9) | 45.0 (44.9–45.1) | 44.9 (44.7–45.1) | 0.379 | 0.398 |
| Sucrose E% | 8.6 (8.5–8.7) | 8.5 (8.5–8.6) | 8.4 (8.3–8.5) | 0.001 | 0.002 |
| Fat E% | 39.3 (39.2–39.5) | 39.2 (39.1–39.4) | 39.3 (39.1–39.5) | 0.793 | 0.883 |
| SFA E% | 17.0 (16.8–17.0) | 16.9 (16.8–17.0) | 16.9 (16.8–17.0) | 0.505 | 0.861 |
| MUFA E% | 13.7 (16.7–16.8) | 13.7 (13.6–13.7) | 13.7 (13.6–13.8) | 0.964 | 0.694 |
| PUFA E% | 6.2 (6.2–6.3) | 6.2 (6.2–6.3) | 6.2 (6.2–6.3) | 0.848 | 0.913 |
| Protein E% | 15.6 (15.6–15.7) | 15.7 (15.7–15.8) | 15.8 (15.7–15.8) | 0.008 | 0.006 |
| Alcohol (g/MJ) | 1.2 (1.2–1.2) | 1.2 (1.2–1.2) | 1.2 (1.2–1.2) | 0.909 | 0.520 |
Values are for mean (95% CI).
a
P for trend across the genotypes.
b
P for trend across the genotypes in sensitivity analysis excluding individuals identified as non-adequate energy reporters.
All analyses are adjusted for age, sex, method, and season.