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Effects of long-term hypoxia on VEGF abundance. Endogenous VEGF levels quantified via Western blot analysis exhibited similar abundances in normoxic and hypoxic fetal sheep. These results suggest that the well-documented increases in VEGF induced on exposure to hypoxia are transient and disappear after 110 days of hypoxic acclimatization. Values are means ± SE for normoxic (n = 7) and hypoxic (n = 5) fetal arteries.
