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Inflammation induced by activated macrophages has inhibitory effects on UCP1 transcriptional activation via ERK activation in white adipocytes. Activated macrophages produce proinflammatory cytokines including TNF-α. TNF-α can suppress UCP1 transcriptional activation induced by β-adrenergic receptor (β-AR)-PKA signaling. ERK activation induced by TNF-α is partially involved in the suppression of the UCP1 mRNA induction.
