Table 1.
Phenotypes of NKCC1 knockout mice
| Phenotype | Mouse | Reference |
|---|---|---|
| Inner ear dysfunction | Delpire, Shull, Koller, Dixon | (25, 28, 38, 106) |
| Small size | Delpire | (25) |
| Male infertility | Delpire, Koller | (25) |
| Postnatal hyperexcitability | Delpire | (162) |
| Postnatal anti-convulsant | Delpire | (33) |
| Pain perception | Delpire | (74, 136) |
| Intestinal transit | Shull | (38) |
| Intestinal transit (ICC) | Delpire | (157) |
| Normal intestinal secretion | Shull | (151) |
| Olfactory neurons | Delpire | (117) |
| Normal olfaction | Shull | (98, 130) |
| Abnormal Cl− currents (DRG) | Delpire | (136) |
| Decreased saliva production | Shull | (36) |
| Normal lung function | Koller | (47) |
| Protection against lung sepsis | Koller | (97) |
| Low blood pressure | Delpire | (Unpublished observations) |
| Low blood pressure | Shull | (38, 92) |
| Normal blood pressure | Shull | (68) |
The table recapitulates the phenotypes reported with each NKCC1 knockout mouse. ICC, interstitial cells of Cajal; DRG, dorsal root ganglion.