A: original trace showing veratridine contraction (in the presence of 60 mM KCl) and its reversal by application of TTX in small mesenteric artery. B: mesenteric contraction to veratridine in the presence of 60 mM KCl. Responses were obtained in the absence (n = 8) and presence of TTX (1 μM, n = 4) or ranolazine (10 μM, n = 5) and TTX + ranolazine (n = 4). **P < 0.01, ***P < 0.001 vs. control (by 1-way ANOVA, followed by Bonferroni's post hoc tests). NS, not significant.