Figure 2.
A) Molecular evaluation of laser-microdissected CD34+ cells in angioimmunoblastic T-cell lymphoma: they express CD31 and not CD10, thus confirming the molecular profile of endothelial cells (left).
Molecular evaluation of laser-microdissected CD3+CD10+ cells in angioimmunoblastic T-cell lymphoma: they express CD10 and not CD31, thus confirming the molecular profile of lymphoma cells (right).
B) Molecular evaluation of laser-microdissected CD34+ cells in lymph node hyperplasia: they express CD31 and not CD10, thus confirming the molecular profile of endothelial cells (left).
Molecular evaluation of laser-microdissected CD3+ cells in lymph node hyperplasia: they express CD3ε and not CD31, thus confirming the molecular profile of lymphocytes (right).
C) The expression of BCL2 mRNA in laser-microdissected CD34+ angioimmunoblastic T-cell lymphoma endothelial cells is significantly correlated with VEGFA mRNA expression levels in the same laser-microdissected cell population (left). BCL2 and VEGFA mRNA expression levels are not correlated in the same laser-microdissected cell population of CD3+CD10+ lymphoma cells of angioimmunoblastic T-cell lymphoma (right).
D) In lymph node hyperplasia controls, no correlations are found between BCL2 and VEGFA mRNA expression levels whether for laser-microdissected CD34+ cells (left) or for laser-microdissected CD3+ lymphocytes (right).