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. 2013 Feb 6;304(8):F1127–F1136. doi: 10.1152/ajprenal.00475.2012

Fig. 5.

Fig. 5.

Effects of GSIXX treatment on Ki67 and synaptopodin expression. Kidneys obtained from GSIXX-treated or vehicle control TG mice were evaluated for the expression of Ki67 and synaptopodin by immunostaining on the paraffin sections. A and B: Ki67 is shown both in glomeruli and tubules. Note a collapsed glomeruli with many Ki67 positive cells in A. GSIXX treatment appeared to reduce Ki67-positive cells in both glomeruli and tubules. C and D: a regain of synaptopodin expression is shown in sections from GSI-treated TG mice (TG GSI) compared with TG veh control. E and F: glomeruli positive for any Ki67 labeling were counted as positive stained, and glomeruli with full expression of synaptopodin were counted positive; others were counted negative for staining. Semiquatitative analysis of the Ki67 and synaptopodin expression in glomeruli is shown. P < 0.05 represents statistical difference compared with WT vehicle and TG vehicle groups (n = 3). *Significant difference vs. the WT vehicle-treated group (P < 0.05).