Fig. 10.

Chronic administration of IL-6 does not alter fibrotic response after IR in netrin-1 transgenic mice. Netrin-1 transgenic mice were subjected to sham surgery or IR. Three days after IR, mice received either vehicle (0.1% BSA) or IL-6 (10 10 ng·animal⁻¹·day⁻¹) for 2 wk. Fibrosis was determined by Masson's trichrome staining, and kidney function was determined by measuring serum creatinine. A: IR-induced interstitial fibrosis is largely suppressed as expected (blue staining) in vehicle-treated netrin-1 transgenic mice. B: IL-6 administration did not increase fibrosis. C: kidney function was determined by measuring serum creatinine. IL-6 administration does not alter serum creatinine levels compared with vehicle-treated IR; n = 6–8.